Mission: Cure
Cycle 2
Chronic pancreatitis is the inflammation of the pancreas, the organ that produces digestive enzymes and insulin. The continued inflammation leads to permanent damage and scarring of the pancreas. This scarring causes digestive problems and eventually leads to diabetes. Chronic pancreatitis patients experience extreme abdominal pain and are at exceptionally high risk for pancreatic cancer.
Last updated May 2024
Clinical
Disease Class
Rare abdominal surgical diseases
Rare diseases due to toxic effects
Rare gastroenterological diseases
Rare genetic diseases
Body Systems
Digestive
Endocrine
Organs
Pancreas
Genes
CASR
CEL
CFTR
CTRC
PRSS1
SPINK1
Type of Inheritance
Autosomal dominant
Not specified / unknown
Disease Mechanism(s)
Ion channel dysfunction
Pathogenic mutation
Protein misfolding
Age of Onset
Adolescence (12-17)
Adulthood (age 18-64)
Early childhood (age 1+-5)
Elderly (age 65+)
Infancy (age 0-1)
Middle childhood (6-11)
Incidence
Less than 10
Prevalence
10000+
Populations and/or ancestry with higher prevalence
African Americans
Symptoms / Phenotypes
diabetes
diarrhea
fatigue
malnutrition
oily or fatty stools / steatorrhea
pain, abdominal
pain, chronic
vomiting / nausea
weight loss
Biomarkers
None
Existing Therapies
Alternative treatments (eg. nutritional supplements)
· Diet Modification, Nutritional Supplements (curcumin, Vitamin D, N-Acetyl Cystene), Meditation, Cognitive Behavioral Therapy
Drugs approved for the symptoms
Drugs used off-label
· CFTR Modulators
Organizational & Research
Cell Lines
iPSCs
Organoids
Cell Lines, location
Not specified
Cell Lines, share
Unknown
Disease Model
Mouse
Organoids
Rat
Disease Model, location
Not specified
Disease Model, share
Unknown
Clinical Trial Role
Funding
Meeting with regulators
Outcome measures, development
Recruitment and outreach, patients
Recruitment and outreach, trial sites/physicians
Results dissemination, publication
Study material design, review (not protocol)
Study protocol design, review
Biobank
None
Center of Excellence
Johns Hopkins Hospital
Registry
Yes, we have collaborated on a registry
Data Collected, Registry
Not specified
Platform, Registry
Not specified
Natural History Study
No, we do not have a natural history study, but we plan to create or collaborate on one
FDA Patient Listening Session
No
FDA Patient-Focused Drug Development (PFDD) Program
Yes
ICD Codes
Yes, we have an ICD-10 code specific to our exact disease
Yes, we have an ICD-11 code specific to our exact disease
Diagnostic Guidelines
No
Clinical/Treatment Guidelines
No
Organizational Roles
Executive Director
Patient Engagement Manager/Director
Research/Scientific Director
Science Advisory Board Policies
Does not have an SAB
Research Network Policies
Does not have a CRN
Research Roadmap
Yes we have a Research Roadmap, and will share policies
International Chapters
None
International Partners
Europe